Scientific Research
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Effectiveness of Cherries in Reducing Uric Acid and Gout: A Systematic Review
Can cherries naturally stop gout pain? A review of six scientific studies suggests the answer is yes. Researchers found that cherry intake could lower dangerous uric acid levels and reduce...
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Phyllanthus Niruri L. Exerts Protective Effects Against the Calcium Oxalate-Induced Renal Injury via Ellagic Acid
In this retrospective cohort study, adding boldine, Phyllanthus niruri, and Ononis spinosa to tamsulosin was associated with higher distal ureteral stone expulsion rates, shorter expulsion time, and reduced pain medication...
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How Metabolite Profiling Reveals New Clues About Serum Urate
This 2013 study used large-scale metabolite profiling and Gaussian graphical modeling to build a serum urate–centered metabolic network in 1,764 adults from the KORA F4 cohort. The researchers found that...
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Phyllanthus Niruri, Ellagic Acid, and Kidney Protection From Calcium Oxalate Damage
This chanca piedra kidney stones study, published in 2022, reports that ellagic acid from Phyllanthus niruri reduced calcium oxalate–induced kidney injury in human kidney cells and a mouse model. The...
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Phyllanthus niruri Leaf Extract and Kidney Oxidative Stress in Diabetic Rats
This 2014 scientific paper examines phyllanthus niruri extract and kidney oxidative stress in a rat model of streptozotocin-induced diabetes. The authors report that an aqueous leaf extract showed in vitro...
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Phyllanthus Niruri and Kidney Stones: What This 2018 Study Found
This 2018 prospective study examines phyllanthus niruri benefits for kidney health in 56 adults with small kidney stones. The authors found that a standardized Phyllanthus niruri infusion increased urinary magnesium...
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Metabolomic Clues That Distinguish Gout from Asymptomatic Hyperuricemia
This pilot study examines hyperuricemia and gout using plasma and urinary metabolomics alongside urate transporter genetics in men with gout and men with asymptomatic hyperuricemia. The authors report differences in...
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Four Key Metabolite Biomarkers That Track Gouty Arthritis Progression
This scientific paper, published in August 2022, examines gout biomarkers by tracking how four specific serum metabolites change as gouty arthritis progresses. The authors found that KYNA, 2PY, 2AMIA, and...
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What a Urinary Metabolomics Study Reveals About Gout
In a scientific paper published in October 2018, Li et al. used urine metabolomics to compare urine samples from 35 gout patients and 29 healthy volunteers using gas chromatography–mass spectrometry....
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Gout Pathophysiology: Metabolite Changes and Key Biomarkers From a 2023 Study
This 2023 systematic review and meta-analysis examines gout pathophysiology by combining data from 33 metabolomics studies. The authors identified consistent changes in purine, lipid, immune-related, and kidney-related metabolites that distinguish...
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How Uric Acid Metabolism Connects to Key Metabolites
Uric acid metabolism involves more than the final step of purine breakdown. This study maps how uric acid metabolism connects to amino acids, peptides, and hormone-related metabolites in more than...
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Powerful Healing Plant: The Science Behind Phyllanthus amarus
The scientific study explores the extensive medicinal potential of Phyllanthus amarus, a traditional herb known for liver protection, antiviral, antidiabetic, and antioxidant effects. It highlights the plant’s rich phytochemical profile...