Can Cocaine Cause Kidney Stones? Understanding the Risks and Realities

Posted by Alerna Kidney Health on

  • Cocaine, derived from the coca plant, provides a temporary high but has harmful effects on multiple organs, including the heart, lungs, brain, and kidneys.
  • Immediate risks include cardiovascular, neurological, respiratory, and gastrointestinal issues. Long-term consequences encompass addiction, organ damage, cognitive impairment, and social/economic problems.
  • While a direct link between cocaine use and kidney stones isn't fully established, cocaine can induce acute kidney injury (AKI), potentially contributing to stone formation. Cocaine-related diseases can strain the kidneys and increase stone risk.
  • These mirror general kidney stone symptoms, such as severe side/back pain, blood in urine, frequent urination, and nausea.
  • Staying hydrated, a balanced diet, limiting sodium, regular exercise, and using natural supplements like chanca piedra—a traditional remedy for kidney stones—can support kidney health. It's essential to seek professional help if struggling with cocaine addiction.

Cocaine, a powerful and highly addictive stimulant, has been associated with a wide range of health issues, including cardiovascular problems, stroke, and organ damage. One question that often arises is whether cocaine use can lead to kidney stones.

In this article, we will examine the risks of cocaine use, its impact on kidney health, and the potential connection between cocaine and kidney stones.

What Is Cocaine and How Does It Affect the Body?

Cocaine is a powerful drug that is often used recreationally for its stimulating effects. It's derived from the coca plant, which is native to South America. Cocaine can be found in two forms: a white powder that's usually snorted and a crystal form known as "crack" cocaine that's typically smoked.

When a person uses cocaine, they may experience a rush of excitement and energy, along with increased alertness. This is because cocaine affects the brain by increasing the levels of certain chemicals that are responsible for making us feel good. However, these effects are only temporary, and they're often followed by a "crash," where the person may feel tired, irritable, and depressed.

The effects of cocaine on the body go beyond the initial "high." Cocaine can also have harmful effects on various parts of the body, including the heart, lungs, brain, and kidneys.1

Risks and Consequences of Cocaine Use

Cocaine use carries both immediate and long-term risks and consequences for the user. Its effects on the central nervous system, cardiovascular system, and other organ systems are profound and can lead to serious health issues. Here are some of the risks and consequences associated with cocaine use:

Immediate Risks:

  • Cardiovascular issues: Increased heart rate and blood pressure, chest pain, arrhythmias, heart attack, stroke.
  • Neurological effects: Confusion, agitation, paranoia, hallucinations, seizures.
  • Respiratory issues: Shortness of breath, coughing, lung damage (especially from smoking crack cocaine).
  • Gastrointestinal effects: Nausea, vomiting, abdominal pain, bowel gangrene.

white pills

Long-Term Consequences:

  • Addiction: Physical and psychological dependence, tolerance, increased risk of overdose.
  • Organ damage: Heart, liver, kidney, and lung damage, chronic diseases.
  • Cognitive impairment: Memory, attention, and decision-making problems, mood disorders.
  • Social and economic consequences: Poor job performance, unemployment, financial difficulties, strained relationships, legal issues.
  • Overdose: Risk of life-threatening conditions, especially when combined with other substances.
  • Withdrawal symptoms: Fatigue, sleep disturbances, irritability, depression, cravings.

It is essential to understand the risks and consequences of cocaine use and to seek help if you or a loved one is struggling with cocaine addiction. Consult with healthcare professionals and addiction specialists for guidance and support in overcoming addiction and achieving a healthier lifestyle.

Cocaine and Kidney Stones: Is There a Connection?

Cocaine use is associated with several adverse effects on the body, particularly on the cardiovascular, neurological, and renal systems. However, the relationship between cocaine use and kidney stones is not as well-established as other effects of the drug.

Cocaine can cause changes in the kidney's function and structure, which could potentially contribute to the formation of kidney stones. Below we will explore how cocaine affects your organs and, specifically, your kidneys.

How Does Cocaine Affect Your Organs?

man in red not feeling well

Cocaine affects multiple organs in the body due to its impact on the central nervous system.5 It works by increasing dopamine, serotonin, and norepinephrine levels in the brain, leading to euphoria, increased energy, and alertness. Here are the effects on different organs:

  1. Heart: Increases heart rate and blood pressure, narrows blood vessels, strains the heart, and can cause arrhythmias and heart attacks.
  2. Brain: Affects reward pathways, making it addictive. Chronic use may result in cognitive impairment, mood disorders, and stroke risk.
  3. Lungs: Smoking crack cocaine damages lungs, causing cough, wheezing, and infections, as well as pulmonary edema and respiratory failure.
  4. Liver: Cocaine is primarily metabolized in the liver, and chronic use can cause liver damage, including fatty liver, hepatitis, and cirrhosis.
  5. Intestines: Reduces blood flow to the intestines, causing abdominal pain, nausea, vomiting, and, in severe cases, bowel gangrene.

How Does Cocaine Affect Your Kidney?

Cocaine's potent stimulating properties have significant impacts on various body organs, including the kidneys. It activates the sympathetic nervous system, causing a cascade of reactions that can be detrimental to renal health.123 Here's a breakdown of how cocaine affects the kidneys:

  1. Acute Kidney Injury (AKI): Cocaine abuse can lead to AKI through various mechanisms like rhabdomyolysis, vasculitis, infarction, thrombotic microangiopathy, and malignant hypertension.1
  2. Rhabdomyolysis: Cocaine can cause traumatic and non-traumatic injuries to skeletal muscles, leading to muscle breakdown and the release of myoglobin, a protein harmful to the kidneys.1
  3. Acute Interstitial Nephritis (AIN): AIN results from inflammation within kidney interstitial tissue. Cocaine-associated cases are rare but documented. Patients with AIN may show elevated creatinine levels and specific urinalysis findings.12
  4. Vascular and Interstitial Injury: Cocaine can damage the glomerulus, kidney tubules, blood vessels, and interstitial tissue, leading to both acute and chronic kidney diseases.2
  5. Other Effects: Chronic cocaine use can worsen existing health conditions impacting kidney health. Cocaine and heroin users have a higher risk of HIV, hepatitis, and other conditions leading to kidney diseases. Cocaine's vasoconstrictor properties can cause hypertension, straining and potentially damaging the kidneys.23

Considering the substantial evidence suggesting cocaine's detrimental effects on the kidneys, it becomes crucial for users and healthcare professionals to recognize these potential outcomes. Early recognition and intervention can help prevent irreversible damage to the kidneys.

getting help for cocaine use

How Cocaine Could Lead to Kidney Stones

The specific link between cocaine use and kidney stones is not well-established. However, cocaine-induced AKI may indirectly contribute to kidney stone formation.

Cocaine can lead to rhabdomyolysis, which is the breakdown of skeletal muscle tissue, resulting in the release of myoglobin. This protein can cause AKI and may increase the risk of kidney stones.1 Furthermore, cocaine-related kidney disease can cause kidney dysfunction, which may increase the likelihood of kidney stone formation.

What are the symptoms of kidney stones caused by cocaine?

The symptoms of kidney stones caused by cocaine are similar to those caused by other factors. These may include:

  • Severe pain in the side or back, below the ribs
  • Pain radiating to the lower abdomen and groin
  • Hematuria (blood in the urine)
  • Frequent urination or urgency
  • Nausea and vomiting

If you experience these symptoms and have a history of cocaine use, seek medical attention immediately.

What Research and Medical Experts Say

Numerous studies and medical experts have explored the potential risks and consequences of cocaine use, particularly concerning kidney health. These studies show a consensus that cocaine usage can indeed have detrimental effects on the kidneys. Here's what the research and medical experts have to say:

  1. Multifaceted Impact on Kidneys: Cocaine use can lead to acute kidney injury (AKI) through various mechanisms such as rhabdomyolysis, vasculitis, infarction, thrombotic microangiopathy, and malignant hypertension.1 Cocaine-induced rhabdomyolysis, which involves muscle breakdown and the release of myoglobin, can cause AKI due to renal vasoconstriction, ischemia, and direct cytotoxicity on proximal tubular tubules. Acute interstitial nephritis (AIN), a rare but reported outcome of cocaine use, involves inflammation in the kidney's interstitium.
  2. Cocaine and Organ Damage: Cocaine use is associated with systemic adverse effects, including its effects on the kidney.12 Cocaine activates the sympathetic nervous system, leading to intense vasoconstriction, endothelial dysfunction, oxidative stress, and platelet activation. Overstimulation of the adrenergic system by cocaine can lead to irreversible organ damage.1
  3. Chronic Kidney Disease: Chronic cocaine use can exacerbate existing health conditions impacting kidney health.2 Individuals who use both cocaine and heroin have an elevated risk of contracting HIV and hepatitis, which can lead to kidney diseases. Furthermore, cocaine's vasoconstrictor properties can cause hypertension, which can lead to chronic kidney disease.3
  4. Cocaine and Renal Arteriosclerosis: Cocaine abuse is associated with accelerated renal arteriosclerosis, which involves the hardening of the renal arteries.4 This process can occur even in the absence of hypertension and contributes to long-term kidney damage.
  5. Importance of Early Recognition: Cocaine-induced kidney injury can be reversible if detected early.1 Early recognition of cocaine-related kidney injury can prevent significant deterioration in renal function and potential progression to chronic kidney failure and the need for permanent hemodialysis.

Medical experts stress the importance of early recognition of cocaine-related kidney injuries, the need for appropriate diagnosis and treatment, and awareness of the multifactorial causes of cocaine-induced AKI.1234 Patients who use cocaine should be aware of the risks associated with its use and should seek medical advice promptly if they experience any symptoms of kidney problems.

Staying Healthy and Preventing Kidney Stones: Ways to Keep Your Kidneys Healthy

exercise and kidney stones

Taking care of your kidneys is crucial to your overall health and well-being. Your kidneys play an essential role in filtering waste and excess fluids from your blood, maintaining a balance of electrolytes, and regulating blood pressure, among other functions.78 Here are some ways you can protect your kidney health and prevent kidney stones:

  • Stay Hydrated: Drink at least 8 to 10 cups of water a day to help flush toxins from your body and support your kidneys in their essential functions.
  • Eat a Balanced Diet: Consume fruits, vegetables, whole grains, and lean proteins. Limit salt, sugar, and processed foods to reduce high blood pressure and obesity risks.
  • Limit Sodium and Protein: Reduce sodium-rich processed and fast foods—moderate animal protein intake to decrease kidney stone and disease risks.
  • Exercise Regularly: Engage in physical activity to lower blood pressure, reduce weight, and support overall health, benefiting kidney function.
  • Manage Chronic Conditions: Follow recommendations for managing chronic conditions like diabetes or high blood pressure, which can adversely affect kidney health.
  • Use Natural Supplements: Use supplements like chanca piedra, the "stone breaker," traditionally used to break down and prevent kidney stones. Studies suggest it may benefit kidney health.6

FInd out how Chanca Piedra can help manage kidney stones

Remember that maintaining a healthy lifestyle is crucial for protecting your kidneys and preventing kidney stones. If you have concerns about your kidney health or are at risk for kidney stones, consult your healthcare provider for personalized advice and recommendations.

How to Seek Professional Help For Cocaine Use

If you or someone you know is struggling with cocaine use, it's crucial to seek professional help. Cocaine addiction can have severe physical and mental health consequences, and professional assistance is often necessary to break the cycle of addiction.

  1. Consult a healthcare provider: Your primary care physician, psychiatrist, or nurse practitioner can help assess your condition and recommend treatment options.
  2. Consider therapy: Therapists, psychologists, and counselors specializing in addiction can offer effective techniques for coping with cravings and addressing the root causes of addiction.
  3. Explore support groups: Narcotics Anonymous (NA) or Cocaine Anonymous (CA) provides a safe space to share experiences and receive support from others in recovery.
  4. Inpatient or outpatient rehab: Rehab centers offer comprehensive addiction treatment, including medical supervision, therapy, and support. Some facilities provide specialized services tailored to the unique needs of individuals with cocaine addiction.

When to Seek Medical Advice For Kidney Health

It's essential to seek medical attention if you have concerns about your kidney health, especially if you've been using substances like cocaine.9 Indicators that you should seek medical advice include:

  • Persistent pain: Experiencing pain in the lower back, side, or abdomen, which may indicate kidney stones or other kidney issues.
  • Changes in urine: Frequent urination, blood in the urine, or dark-colored urine could indicate kidney problems.
  • Swelling: Swollen ankles, feet, or hands may be signs of kidney issues.
  • Nausea and vomiting: Persistent nausea and vomiting, especially if accompanied by other symptoms, may indicate kidney problems.
  • High blood pressure: Uncontrolled hypertension can contribute to kidney damage.

What is the treatment for kidney stones caused by cocaine?

Kidney stones caused by cocaine use are treated similarly to other types of kidney stones, but the underlying cause must also be addressed.10

  1. Pain management: Over-the-counter pain medications or prescribed medications can help manage pain associated with kidney stones.
  2. Fluid intake: Drinking plenty of water helps to flush out the stones and prevents their recurrence.
  3. Passing the stones: Most small stones will pass on their own with increased fluid intake and pain management.
  4. Medical intervention:11 For larger stones or those causing severe pain, additional medical interventions such as extracorporeal shock wave lithotripsy (ESWL), ureteroscopy, or surgery may be necessary.
  5. Addressing cocaine use through hospitalization and sober housing programs: Seeking professional help for cocaine use is crucial to prevent recurrent kidney stones and other health issues associated with drug abuse.

support group for addiction

It's essential to work with a healthcare professional to determine the appropriate treatment for kidney stones and any underlying issues, such as cocaine use. Proper diagnosis and intervention are critical to preserving kidney health and overall well-being.

Cocaine and Kidney Stones FAQs

Can Coke affect kidney function?

Yes, cocaine can affect kidney function. Cocaine activates the sympathetic nervous system, which can cause a range of reactions that are harmful to the kidneys. These reactions can include acute kidney injury, rhabdomyolysis (muscle breakdown), vasculitis (inflammation of blood vessels), infarction (tissue death due to lack of blood supply), thrombotic microangiopathy (clotting in small blood vessels), and malignant hypertension (severe high blood pressure). Cocaine's harmful effects on the kidneys can result in both acute and chronic kidney diseases.

Can drugs cause kidney failure?

Yes, certain drugs can cause kidney failure. Some medications, both prescription and over-the-counter, as well as recreational drugs, can be harmful to the kidneys. For example, non-steroidal anti-inflammatory drugs (NSAIDs), certain antibiotics, and some antiviral drugs can have toxic effects on the kidneys.

Which drugs are bad for your kidneys?

Several drugs can be harmful to your kidneys, including:

  1. Non-steroidal anti-inflammatory drugs (NSAIDs): Such as ibuprofen and naproxen, can decrease blood flow to the kidneys, leading to kidney damage with long-term use.
  2. Certain antibiotics: Some antibiotics, especially aminoglycosides, can cause kidney damage.
  3. Certain antiviral drugs: Such as tenofovir and indinavir, can be harmful to the kidneys.
  4. Proton pump inhibitors (PPIs): Used to treat heartburn, can increase the risk of kidney disease.
  5. Certain antifungal drugs: Such as amphotericin B, can have toxic effects on the kidneys.
  6. Recreational drugs: Including cocaine, heroin, and methamphetamine, can cause direct kidney damage or worsen existing health conditions that impact kidney health.

It's essential to use medications as prescribed and to discuss any concerns about your medications' effects on your kidneys with your healthcare provider.

Medical Disclaimer:

The information provided in this article is for educational and informational purposes only and should not be considered a substitute for professional medical advice, diagnosis, or treatment. Please consult with your healthcare provider before starting any new dietary supplement, especially if you are pregnant, nursing, have a medical condition, or are taking other medications. Never disregard professional medical advice or delay in seeking it because of something you have read in this article.


  1. Jahir T, Hossain SMS, Risal R, Schmidt M, Enriquez D, Bagum M. Cocaine Hurts Your Kidneys Too: A Rare Case of Acute Interstitial Nephritis Caused by Cocaine Abuse. Cureus. 2021 Nov 3;13(11):e19236. doi: 10.7759/cureus.19236. PMID: 34877213; PMCID: PMC8642135.
  2. Goel N, Pullman JM, Coco M. Cocaine and kidney injury: a kaleidoscope of pathology. Clin Kidney J. 2014 Dec;7(6):513-7. doi: 10.1093/ckj/sfu092. Epub 2014 Sep 12. PMID: 25859366; PMCID: PMC4389131.
  3. Filho, J.C.C.L., Ogawa, M.Y., de Souza Andrade, T.H. et al. Spectrum of acute kidney injury associated with cocaine use: report of three cases. BMC Nephrol 20, 99 (2019).
  4. Fokko J. van der Woude, Cocaine use and kidney damage, Nephrology Dialysis Transplantation, Volume 15, Issue 3, March 2000, Pages 299–301,
  5. Effect of Drugs on the Kidneys | Kidney Damage & Failure. (n.d.). Accessed 22 August 2023.
  6. Pucci ND, Marchini GS, Mazzucchi E, Reis ST, Srougi M, Evazian D, Nahas WC. Effect of phyllanthus niruri on metabolic parameters of patients with kidney stone: a perspective for disease prevention. Int Braz J Urol. 2018 Jul-Aug;44(4):758-764. doi: 10.1590/S1677-5538.IBJU.2017.0521. PMID: 29617079; PMCID: PMC6092661.
  7. Kidney stones - Prevention. Accessed 22 August 2023.
  8. How to prevent kidney stones - Harvard Health. (2013, October 4). Harvard Health. Accessed 22 August 2023.
  9. 10 Signs You May Have Kidney Disease. (2020, December 17). National Kidney Foundation. Accessed 22 August 2023.
  10. Eating, Diet, & Nutrition for Kidney Stones - NIDDK. (2017, May 1). National Institute of Diabetes and Digestive and Kidney Diseases. Accessed 22 August 2023.
  11. Treatment for Kidney Stones - NIDDK. (2017, May 1). National Institute of Diabetes and Digestive and Kidney Diseases. Accessed 22 August 2023.

← Older Post Newer Post →