How Quickly Does Prednisone Work for Gout?

Posted by Alerna Kidney Health on

  • Prednisone, a synthetic corticosteroid, effectively treats gout by reducing inflammation and pain.
  • The medication typically offers initial relief from gout symptoms within 1 to 3 hours of ingestion.
  • A full course of Prednisone for gout usually involves a tapering dosage over 10 to 14 days.
  • Lifestyle changes, including diet and exercise, complement Prednisone treatment for gout management.
  • It's important to consult a healthcare provider for any concerns or persistent symptoms during Prednisone treatment.

Gout, a complex form of arthritis, is characterized by sudden, severe attacks of pain, swelling, redness, and tenderness in the joints, often the joint at the base of the big toe.1

Gout is characterized by sudden, severe attacks of pain, swelling, redness, and tenderness in the joints.

An attack of gout can occur suddenly, often waking you up in the middle of the night with the sensation that your big toe is on fire. The affected joint is hot, swollen, and so tender that even the weight of the sheet on it may seem intolerable.

Fortunately, gout is treatable, and there are ways to reduce the risk of recurring gout. One of the effective treatments is Prednisone, a corticosteroid drug that relieves the painful symptoms of gout.

What is Prednisone?

Prednisone is a synthetic corticosteroid drug miming the anti-inflammatory and immunosuppressive effects of cortisol, a natural steroid hormone produced by the adrenal glands.2

As a medication, it is widely used in treating various inflammatory and autoimmune conditions, including asthma, allergic reactions, ulcerative colitis, and rheumatoid arthritis, besides its use in managing gout flare-ups.

Prednisone reduces inflammation, which is a key contributor to the symptoms associated with these conditions.

How Prednisone Works in Treating Gout

Prednisone is particularly effective in treating gout due to its strong anti-inflammatory properties.3 Gout occurs due to the accumulation of urate crystals in a joint, causing intense pain and inflammation.

Prednisone helps by reducing the inflammation around the urate crystals, alleviating pain and swelling during a gout attack.

The effectiveness of Prednisone in managing gout symptoms makes it a valuable option, especially for patients who cannot take nonsteroidal anti-inflammatory drugs (NSAIDs) or colchicine, other common treatments for gout attacks.3

Prednisone, a synthetic corticosteroid, effectively treats gout by reducing inflammation and pain.

How Long Before Prednisone Starts Working

Initial Relief

The onset of action for Prednisone is relatively quick. Patients often experience a noticeable decrease in pain and swelling within hours of taking the medication.

Studies indicate that prednisone and prednisolone, its active form, reach peak plasma concentrations in adults after about 1 to 3 hours following oral administration, which correlates with the initial relief of symptoms.4,5

Full Effect

While the initial effects of Prednisone are rapid, the full therapeutic impact of the medication on gout symptoms may take a few days to manifest.

This delay is due to the time required for Prednisone to comprehensively influence the inflammatory processes associated with gout.

Patients may start to feel substantial relief within a day or two, but the maximum effect might be observed only after a few days of continuous treatment.

Factors That May Affect the Speed of Relief

Several factors can influence how quickly a patient experiences relief from gout symptoms after taking Prednisone. These include:

  1. Dosage: Higher doses may provide quicker relief but also increase the risk of side effects.
  2. Individual Metabolism: Variations in liver function and metabolic rate can affect how quickly Prednisone is processed and becomes effective.
  3. Severity of the Attack: More severe gout attacks might take longer to respond to treatment.
  4. Concurrent Medications: Other medications can interact with Prednisone, potentially altering its effectiveness.
  5. Overall Health: General health and other medical conditions can influence the drug's efficacy.

Understanding these factors can help manage expectations regarding the time it takes for Prednisone to provide relief from gout symptoms and can guide discussions with healthcare providers about the appropriate treatment plan.

Prednisone for Gout: Dosage and Administration

The effectiveness of Prednisone in treating gout depends significantly on the appropriate dosage and administration. Typically, the initial dosage for acute gout flare-ups ranges from 30 to 40 mg per day. This dosage is then gradually tapered over 10 to 14 days to prevent the risk of recurrent gout attacks and minimize potential side effects.3

The tapering process is crucial as it helps the body adjust to the decrease in steroid levels, thereby reducing the risk of withdrawal symptoms. Patients must follow their doctor's prescription closely, maintain the dosage, and suddenly stop the medication without medical consultation.

The medication typically offers initial relief from gout symptoms within 1 to 3 hours of ingestion.

Comparison with Other Gout Treatments

Prednisone is one among several medications used for treating gout. Other common treatments include NSAIDs and colchicine. NSAIDs, such as ibuprofen and naproxen, are often the first line of treatment for gout and work by reducing inflammation and pain.3

However, they are not suitable for everyone, especially those with kidney problems or a history of stomach ulcers. Colchicine is effective in reducing gout pain but can have gastrointestinal side effects.

The choice between these medications depends on individual patient factors like existing health conditions, other medications being taken, and the side effect profile of each drug. Prednisone is often preferred in patients who have contraindications to NSAID use or experience severe side effects from colchicine.

Potential Side Effects

While Prednisone is effective in managing gout symptoms, it comes with a range of potential side effects.

Common side effects include mood swings, increased blood sugar levels, and elevated blood pressure. Long-term use can lead to more serious effects, such as osteoporosis, cataracts, and an increased risk of infection.2

Patients on Prednisone should be monitored regularly for these side effects, and any unusual symptoms should be reported to a healthcare provider immediately.

Lifestyle Adjustments to Support Treatment

Managing gout effectively goes beyond medication; lifestyle adjustments are critical in supporting treatment and preventing future flare-ups. These adjustments can significantly impact the frequency and severity of gout attacks.

Diet Modifications

  • Limit Purine-Rich Foods: Foods high in purines, such as red meats, organ meats (like liver and kidneys), and certain seafood (like anchovies, sardines, and mackerel), should be consumed in moderation. Purines can increase uric acid levels in the body, exacerbating gout symptoms.1
  • Increase Dairy Intake: Low-fat dairy products have been associated with a lower risk of gout. Including more milk, yogurt, and cheese in the diet might help manage uric acid levels.
  • Fruits and Vegetables: A diet rich in fruits, vegetables, whole grains, and legumes can help reduce inflammation and improve overall health, benefiting those with gout.
  • Complex Carbohydrates: Foods high in complex carbohydrates, like whole grains and vegetables, are beneficial. They not only provide essential nutrients but also help in maintaining a healthy weight.
Lifestyle changes, including diet and exercise, complement Prednisone treatment for gout management.


  • Water: Drinking plenty of water helps dilute uric acid and promotes its excretion through urine. Aim for at least 8-10 glasses of water daily, especially during a gout attack.6
  • Limit Alcohol and Sugary Drinks: Alcohol, especially beer, and drinks sweetened with high-fructose corn syrup can increase uric acid levels. Limiting or avoiding these beverages can help in managing gout.6

Weight Management and Exercise

  • Healthy Weight: Maintaining a healthy weight reduces the stress on joints and lowers the risk of gout attacks. Gradual weight loss is recommended, as rapid weight loss can temporarily increase uric acid levels.8
  • Regular Exercise: Regular physical activity helps maintain a healthy weight and improves overall well-being. However, avoid high-impact exercises during a gout flare-up to prevent aggravating the affected joint.

Alcohol and Smoking

  • Limit Alcohol Consumption: Alcohol, particularly beer, can trigger gout attacks. Moderation is key.7
  • Avoid Smoking: Smoking can exacerbate inflammation and negatively impact overall health, potentially worsening gout symptoms.

Stress Management

  • Stress Reduction: High stress levels can trigger gout attacks. Practices such as yoga, meditation, and deep breathing exercises can be beneficial in managing stress.6

By incorporating these lifestyle changes, individuals with gout can support their treatment and improve their overall quality of life. Combined with medication and regular medical consultations, these adjustments form a holistic approach to managing gout effectively.

Can Uric Acid Supplements Help?

While Prednisone treats the symptoms of gout, it doesn't address the underlying cause - high uric acid levels. Uric acid supplements, or medications that lower uric acid levels, can be beneficial in managing chronic gout.

These include xanthine oxidase inhibitors like allopurinol, which reduces the production of uric acid, and uricosuric agents, which increase the excretion of uric acid in urine.

However, these should only be taken under medical supervision as they can trigger acute gout attacks when initially started.

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When to Seek Medical Advice

It's important to seek medical advice if there's no improvement in symptoms after starting Prednisone if symptoms worsen, or if severe side effects occur. Also, immediate medical attention is necessary if there are signs of an allergic reaction, such as rash, itching, or difficulty breathing.

Consulting a healthcare provider is also essential when considering new medications or supplements, particularly in ongoing gout treatment.

Conclusion: How Quickly Does Prednisone Work for Gout?

Prednisone is a potent medication for managing the acute symptoms of gout, offering relief within hours to days of starting treatment.

Compared with other treatments, its effectiveness and potential side effects make it a significant option for those unable to use other medications. Alongside pharmacological interventions, lifestyle modifications play a crucial role in managing gout.

Understanding when to seek medical advice and the importance of comprehensive treatment strategies, including managing uric acid levels, is essential for effective gout management.

As with any medication, following the healthcare provider's guidance and reporting any concerns or side effects experienced during treatment is important.

Frequently Asked Questions

How long does prednisone stay in your system?

Prednisone typically takes about 16.5 to 22 hours to be eliminated from your system.

How long does oral prednisone stay in your system?

Oral prednisone is usually out of your system within approximately 16.5 to 22 hours after the last dose.

How long does prednisone stay in my body?

Prednisone remains in the body for around 18 hours post the last dose, accounting for about 5 to 6 half-lives.

Medical Disclaimer:

The information provided in this article is for educational and informational purposes only and should not be considered a substitute for professional medical advice, diagnosis, or treatment. Please consult with your healthcare provider before starting any new dietary supplement, especially if you are pregnant, nursing, have a medical condition, or are taking other medications. Never disregard professional medical advice or delay in seeking it because of something you have read in this article.


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  2. Puckett Y, Gabbar A, Bokhari AA. Prednisone. [Updated 2023 Jul 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from:
  3. Prasad S, Ewigman B. Acute gout: oral steroids work as well as NSAIDs. J Fam Pract. 2008 Oct;57(10):655-7. PMID: 18842190; PMCID: PMC3183840.
  4. Scherholz ML, Schlesinger N, Androulakis IP. Chronopharmacology of glucocorticoids. Adv Drug Deliv Rev. 2019 Nov-Dec;151-152:245-261. doi: 10.1016/j.addr.2019.02.004. Epub 2019 Feb 21. PMID: 30797955; PMCID: PMC6703983.
  5. Bashar T, Apu MNH, Mostaid MS, Islam MS, Hasnat A. Pharmacokinetics and Bioavailability Study of a Prednisolone Tablet as a Single Oral Dose in Bangladeshi Healthy Volunteers. Dose Response. 2018 Jul 25;16(3):1559325818783932. doi: 10.1177/1559325818783932. PMID: 30083083; PMCID: PMC6073839.
  6. Kakutani-Hatayama M, Kadoya M, Okazaki H, Kurajoh M, Shoji T, Koyama H, Tsutsumi Z, Moriwaki Y, Namba M, Yamamoto T. Nonpharmacological Management of Gout and Hyperuricemia: Hints for Better Lifestyle. Am J Lifestyle Med. 2015 Sep 2;11(4):321-329. doi: 10.1177/1559827615601973. PMID: 30202351; PMCID: PMC6125106.
  7. Syed AAS, Fahira A, Yang Q, Chen J, Li Z, Chen H, Shi Y. The Relationship between Alcohol Consumption and Gout: A Mendelian Randomization Study. Genes (Basel). 2022 Mar 22;13(4):557. doi: 10.3390/genes13040557. PMID: 35456363; PMCID: PMC9028689.
  8. Juraschek SP, Miller ER 3rd, Gelber AC. Body mass index, obesity, and prevalent gout in the United States in 1988-1994 and 2007-2010. Arthritis Care Res (Hoboken). 2013 Jan;65(1):127-32. doi: 10.1002/acr.21791. PMID: 22778033; PMCID: PMC3482278.
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