Free standard shipping and returns on all orders

Free standard shipping and returns on all orders

Your cart

Your cart is empty

A healthcare professional holding and pointing at a knee model.

What Is the Best Supplement for Joint Health? Top Supplements for Joint Pain and Flexibility

Many people turn to supplements as a natural way to support joint health and manage discomfort. Joint issues like stiffness, inflammation, and pain are common, especially for those with arthritis or knee osteoarthritis. Certain supplements are commonly used to support joint health and may help with flexibility and comfort. This article reviews the best supplements for joint health, backed by research, to help you find the most effective options for pain relief and mobility.

Why Are Joint Health Supplements Important?

Joint supplements help fill nutritional gaps by supporting cartilage structure, reducing inflammation, and relieving joint pain. Certain supplements, such as glucosamine and chondroitin, help rebuild cartilage, while others, like omega-3 fatty acids, provide anti-inflammatory benefits to ease joint stiffness.


Supplements work best when combined with a healthy lifestyle. A balanced diet rich in antioxidant vitamins, regular exercise, and maintaining a healthy weight can enhance their effects. Managing joint health early can help reduce the risk of arthritis symptoms and long-term joint disease.

A healthcare professional holding and pointing at a knee model.

What Are the Best Supplements for Joint Health?

Several dietary supplements have been studied for their ability to support joint health, reduce inflammation, and relieve arthritis pain. The following are some of the most effective options based on research.

Glucosamine and Chondroitin

Glucosamine and chondroitin are widely used joint supplements that may help support cartilage and reduce joint pain. These natural compounds support connective tissue and may slow the progression of knee osteoarthritis by protecting cartilage from breakdown.


Some studies suggest glucosamine sulfate and chondroitin supplements may help with joint discomfort and function, though results vary. Studies published in Arch Orthop Trauma Surg indicate that they may be particularly beneficial for people experiencing joint pain from osteoarthritis.

Close-up of knee model with protective cartilage layer.

Turmeric and Curcumin

Turmeric contains curcumin, a powerful anti-inflammatory agent that may help reduce joint swelling and stiffness. Some studies suggest curcumin may help with joint inflammation, though more research is needed to determine how it compares to arthritis medications.


Some research indicates that combining curcumin with piperine may improve its absorption. This combination helps improve absorption, allowing the body to maximize its anti-inflammatory properties for joint pain relief.

Turmeric powder and capsules.

Collagen Peptides

Collagen is essential for maintaining cartilage structure and supporting joint elasticity. Natural collagen production decreases as people age, leading to joint stiffness and increased risk of arthritis symptoms. Supplementing with collagen peptides can help maintain joint flexibility and repair cartilage damage.


Collagen supplements may support joint health, particularly in active individuals or those with age-related joint stiffness. Research suggests regular intake can support bone strength and improve joint health.

Omega-3 Fatty Acids (Fish Oil)

Omega-3 fatty acids, found in fish oil, have strong anti-inflammatory properties that help reduce joint pain and stiffness. These fatty acids have anti-inflammatory properties that may help ease joint discomfort in some individuals with arthritis.


Some research suggests omega-3s may help reduce inflammation, which could support joint health. They may also work alongside other supplements for arthritis, enhancing their pain-relieving effects.

A well-arranged plate featuring grilled salmon.

MSM (Methylsulfonylmethane)

MSM is a natural compound that may help support joint health and reduce inflammation. It supports collagen production, which is essential for maintaining cartilage and connective tissue health.


Some research suggests that MSM may also help reduce muscle soreness and improve recovery after physical activity. It is often commonly included in joint supplements alongside glucosamine and chondroitin, though its benefits may vary.

How to Choose the Right Supplement for Your Joint Health Needs

Selecting the best joint supplement depends on your specific symptoms, overall health, and the quality of the product. Understanding what each supplement offers can help you make an informed decision.

Consider Your Specific Joint Issues

Different supplements target different joint problems. Choosing the right one depends on whether you need pain relief, inflammation control, or cartilage support.


  • For inflammation and stiffness – Omega-3 fatty acids, turmeric, and MSM help reduce inflammation and improve mobility.

  • For cartilage damage and joint strength – Glucosamine, chondroitin, and collagen peptides support cartilage repair and joint elasticity.

  • For overall joint health and flexibility – A combination of glucosamine sulfate, chondroitin sulfate, and MSM may provide the best results.

Look for High-Quality, Tested Products

Not all dietary supplements are created equal. Choosing high-quality, tested products ensures safety and effectiveness.


  • Third-party testing – Look for supplements verified by organizations like NSF International or USP.

  • No unnecessary additives – Avoid products with artificial fillers, preservatives, or food allergens.

  • Reputable brands – Choose brands with strong reputations and positive customer reviews.

  • Clinical research backing  – Opt for supplements supported by scientific studies for joint pain relief.

Dosage and Combining Supplements

Taking the right dosage is essential for effectiveness. Many supplements, like glucosamine hydrochloride and chondroitin sulfate, require consistent daily intake for noticeable results.


Some supplements work better when combined. Glucosamine and chondroitin are often taken together for joint disease management, while turmeric’s anti-inflammatory properties are enhanced when paired with black pepper (piperine).

A glass of golden milk.

Are There Any Side Effects or Risks with Joint Health Supplements?

While joint supplements are generally safe, some may cause mild side effects or interact with medications. It's important to be aware of potential risks.


  • Glucosamine and chondroitin – May cause digestive discomfort, nausea, or allergic reactions in those with shellfish allergies.

  • Fish oil (omega-3 fatty acids) – Can have blood-thinning effects and may increase bleeding risk, especially for those on blood thinners.

  • Turmeric and curcumin – High doses may cause stomach upset or interfere with certain medications.

  • MSM – Generally well-tolerated but may cause mild bloating or headaches in some individuals.


Consulting with a healthcare provider before starting a new supplement is essential, especially for those taking arthritis medications or over-the-counter pain relievers. A professional can help determine the safest and most effective option based on your health needs.

Woman holding stomach out of discomfort.

Click here to learn more about Alerna's Uric Acid Supplements to enhance your joint and kidney health and overall well-being!

Finding the Right Joint Supplement for Your Needs

Choosing the best supplement for joint health depends on your specific concerns, such as inflammation, cartilage support, or overall flexibility. Glucosamine, chondroitin, turmeric, collagen, and omega-3 fatty acids are among the most effective options for reducing joint pain and stiffness.


High-quality supplements, taken consistently, can provide long-term benefits. Prioritizing reputable brands and proper dosages ensures safety and effectiveness in supporting joint health.

Frequently Asked Questions

How long does it take for joint supplements to work?

Most joint supplements take several weeks to a few months to show noticeable results, depending on the supplement type and individual response.

Can you take multiple joint supplements together?

Certain supplements, like glucosamine and chondroitin or turmeric and black pepper, are often combined for better effectiveness, but it’s important to check for possible interactions.

Are joint supplements safe for long-term use?

Most joint supplements are safe when taken as directed, but regular check-ins with a healthcare provider can help monitor effectiveness and avoid potential side effects.

What is the best supplement for knee osteoarthritis?

Glucosamine sulfate, chondroitin, and omega-3 fatty acids have been studied for their ability to relieve knee osteoarthritis symptoms and support joint function.

Can joint supplements replace arthritis medications?

Joint supplements may help reduce arthritis pain and stiffness, but they should not replace prescribed arthritis medications without consulting a healthcare provider.

Medical Disclaimer:

The information provided in this article is for educational and informational purposes only and should not be considered a substitute for professional medical advice, diagnosis, or treatment. Please consult with your healthcare provider before starting any new dietary supplement, especially if you are pregnant, nursing, have a medical condition, or are taking other medications. Never disregard professional medical advice or delay in seeking it because of something you have read in this article.

References

  1. Calder P. C. (2017). Omega-3 fatty acids and inflammatory processes: from molecules to man. Biochemical Society transactions, 45(5), 1105–1115. https://doi.org/10.1042/BST20160474

  2. Daily, J. W., Yang, M., & Park, S. (2016). Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Journal of medicinal food, 19(8), 717–729. https://doi.org/10.1089/jmf.2016.3705

  3. Kalman, D. S., Feldman, S., Scheinberg, A. R., Krieger, D. R., & Bloomer, R. J. (2012). Influence of methylsulfonylmethane on markers of exercise recovery and performance in healthy men: a pilot study. Journal of the International Society of Sports Nutrition, 9(1), 46. https://doi.org/10.1186/1550-2783-9-46

  4. Kongtharvonskul, J., Anothaisintawee, T., McEvoy, M., Attia, J., Woratanarat, P., & Thakkinstian, A. (2015). Efficacy and safety of glucosamine, diacerein, and NSAIDs in osteoarthritis knee: a systematic review and network meta-analysis. European journal of medical research, 20(1), 24. https://doi.org/10.1186/s40001-015-0115-7

  5. Porfírio, E., & Fanaro, G. B. (2016). Collagen supplementation as a complementary therapy for the prevention and treatment of osteoporosis and osteoarthritis: A systematic review. Revista Brasileira de Geriatria e Gerontologia, 19(1), 153-164. https://doi.org/10.1590/1809-9823.2016.14145

  6. Zeng, C., Wei, J., Li, H., Wang, Y. L., Xie, D. X., Yang, T., Gao, S. G., Li, Y. S., Luo, W., & Lei, G. H. (2015). Effectiveness and safety of Glucosamine, chondroitin, the two in combination, or celecoxib in the treatment of osteoarthritis of the knee. Scientific reports, 5, 16827. https://doi.org/10.1038/srep16827 

Related Articles

Previous post