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Magnesium Glycinate and Kidney Stones | Benefits and Considerations

Kidney stones are hard mineral and salt deposits that form in the kidneys, often causing intense pain and discomfort. These stones, primarily made of calcium oxalate or calcium phosphate, develop due to factors like concentrated urine, high oxalate levels, and dietary habits. Common symptoms include severe back pain, blood in the urine, and nausea.


Magnesium glycinate, a highly absorbable form of magnesium, is vital to overall health and wellness. It may help reduce the risk of kidney stone formation by decreasing oxalate absorption and minimizing calcium oxalate crystallization.

Close-up of kidney stones.

Understanding Kidney Stones

Kidney stones come in several types, with the most common being calcium oxalate stones, followed by calcium phosphate stones, uric acid stones, and struvite stones. These stones form when minerals and salts in urine crystallize due to imbalances in the urinary system.


  • Dehydration: Inadequate fluid intake leads to concentrated urine, increasing the likelihood of stone formation.

  • High Oxalate Diet: Foods rich in oxalates, like spinach and nuts, can raise oxalate levels in urine, promoting calcium oxalate crystallization.

  • Excess Salt and Protein Intake:  High salt levels increase urinary calcium excretion, while too much animal protein lowers citrate excretion, both of which contribute to kidney stone formation.

Symptoms and Diagnosis

Diagnosing kidney stones typically involves imaging tests like CT scans, ultrasounds, or X-rays to detect stones and assess their size and location. Urine tests may also help identify risk factors like oxalate levels or calcium excretion.


  • Severe Pain: Intense pain in the lower back, abdomen, or groin, often described as sharp and sudden.

  • Blood in the Urine: Pink, red, or brown urine may indicate the presence of stones causing irritation.

  • Frequent Urination: Increased urgency or difficulty passing urine, sometimes accompanied by nausea or fever.

Human body highlighting common areas affected by kidney stone symptoms.

The Role of Magnesium in Preventing Kidney Stones

Magnesium may reduce the risk of calcium oxalate stone formation by lowering oxalate absorption and limiting calcium oxalate crystallization. It binds to oxalate in the digestive tract, reducing oxalate absorption into the bloodstream.


Additionally, magnesium supports proper calcium metabolism, ensuring calcium is utilized for bone health rather than forming kidney stones. Increasing magnesium intake may also balance citrate levels in urine, which further helps prevent kidney stone formation.

What Does the Research Say?

Research supports the benefits of magnesium supplements, including magnesium glycinate, in kidney stone prevention. Some studies suggest that supplemental magnesium may help reduce the formation of calcium oxalate stones by decreasing oxalate absorption and potentially influencing urinary calcium levels.


Studies suggest that magnesium may inhibit calcium oxalate crystallization, potentially reducing the risk of recurrent calcium oxalate nephrolithiasis. Due to their high absorption rates, clinical evidence also shows that magnesium citrate and magnesium glycinate are especially effective for individuals at risk of developing kidney stones.

Microscopic view of calcium oxalate stone formation.

Benefits of Magnesium Glycinate for Kidney Health

Magnesium glycinate is a highly absorbable form of magnesium created by combining magnesium with the amino acid glycine. This form is gentle on the stomach and provides dual benefits: improving magnesium levels and reducing the risk of calcium oxalate stone formation. Its superior bioavailability makes it an excellent choice for kidney health and overall wellness.

Comparison with Other Forms of Magnesium

Form of Magnesium

Absorption

Kidney Benefits

Side Effects

Magnesium Glycinate

High 

Reduces calcium oxalate crystallization, gentle

Minimal, less likely to cause diarrhea

Magnesium Oxide

Moderate

May prevent stones but less bioavailable

Can cause upset stomach

Magnesium Citrate

High 

Reduces oxalate absorption and urinary calcium levels

May cause loose stools

Magnesium Hydroxide

Low

Limited kidney benefits, often used as an antacid

May lead to magnesium toxicity in high doses

How Does Magnesium Glycinate Support Kidney Health?

Magnesium glycinate may support kidney stone prevention by reducing oxalate absorption in the gut, potentially lowering the risk of calcium oxalate crystal formation. It also balances urinary calcium and citrate levels, decreasing the likelihood of stone recurrence.


Beyond stone prevention, magnesium glycinate supports overall kidney function by aiding in maintaining proper urinary balance and addressing factors that contribute to kidney stone formation. Maintaining adequate magnesium levels can also improve renal health by minimizing the formation of concentrated urine and protecting the kidneys from oxidative stress.

Close-up of white tablets.

How to Use Magnesium Glycinate for Kidney Stone Prevention

Taking magnesium glycinate safely and effectively involves following recommended dosage guidelines. Most adults can take between 200 and 400 mg daily, but a healthcare provider may suggest a specific dose based on individual needs.


Magnesium glycinate should be taken with a meal to improve absorption and reduce the risk of upset stomach. Adequate fluid intake throughout the day enhances its effectiveness in preventing kidney stones.

When Should You Take Magnesium Glycinate?

Taking magnesium glycinate at the right time can optimize its absorption and benefits. It is often best taken in divided doses—morning and evening—to maintain steady magnesium levels in the body. For people taking other supplements, such as potassium citrate or calcium, magnesium glycinate can be spaced a few hours apart to avoid interactions and maximize absorption.


Combining magnesium glycinate with a healthy diet rich in low-oxalate foods and proper hydration may support kidney stone prevention. Foods like leafy greens, citrus fruits, and whole grains complement magnesium supplementation by providing additional nutrients that support kidney health.

Potential Side Effects and Considerations

Magnesium glycinate is generally well-tolerated, but like any supplement, it can cause side effects in some individuals. Understanding these effects and how to manage them can help ensure safe use.


  • Upset Stomach: Mild gastrointestinal discomfort may occur, such as nausea or diarrhea. Taking magnesium glycinate with food can reduce this risk.

  • Low Blood Pressure: High doses may lower blood pressure. Monitor blood pressure regularly, especially if you are prone to hypotension.

  • Magnesium Toxicity: Rare but possible in individuals with kidney issues or excessive doses. Symptoms include weakness, difficulty breathing, and irregular heartbeat. Stick to recommended dosages to prevent this.


Seek medical advice if side effects persist or worsen. Immediate attention is necessary for signs of magnesium toxicity or allergic reactions, such as swelling, hives, or difficulty breathing.

Who Should Avoid Magnesium Glycinate?

Magnesium glycinate is not suitable for everyone. Individuals with specific health conditions, such as severe kidney disease, should avoid it, as impaired kidney function can lead to magnesium accumulation and toxicity. People with heart block or extremely low blood pressure should also consult a healthcare provider before use.


Magnesium glycinate may interact with certain medications, including diuretics, antibiotics, and blood pressure medications. These interactions can affect the effectiveness of the drugs or increase the risk of side effects. Always inform your healthcare provider about any supplements you are taking to avoid complications.

Person holding white tablets.

Other Natural Ways to Prevent Kidney Stones

Preventing kidney stones naturally involves making changes to your diet and lifestyle that support kidney health. Incorporating specific foods, staying hydrated, and adopting healthy habits can significantly reduce the risk of stone formation and promote overall wellness.

What Dietary Changes Can Help?

Diet plays a crucial role in kidney stone prevention. Including low-oxalate foods like bananas, citrus fruits, and wheat bran can lower the risk of calcium oxalate stone formation. Foods rich in magnesium, such as leafy greens, almonds, and avocados, can also help reduce oxalate absorption.


Avoiding high-oxalate foods like spinach, nuts, and chocolate is equally important. Limiting salt and animal protein reduces urinary calcium excretion and promotes a balanced urine composition. Combining these dietary changes with a low-oxalate diet can reduce the risk of forming stones.


Staying hydrated is another essential strategy. Drinking enough water dilutes urine, preventing the concentration of minerals that lead to stone formation. Aim for at least 8-10 glasses of water daily, and include fluids like citrus fruit juices, which increase citrate excretion.

What Lifestyle Modifications Are Beneficial?

Regular physical activity can help prevent kidney stones by maintaining a healthy body weight. Excess body weight increases the risk of stone formation due to higher urinary oxalate and calcium levels. Moderate exercise like walking or cycling can improve kidney health and reduce risk factors.


Stress management also plays a role in preventing kidney stones. Chronic stress can raise cortisol levels, possibly contributing to higher urinary calcium excretion. Techniques like yoga, meditation, and deep breathing exercises reduce stress and support overall kidney health. Combining these practices with dietary and hydration habits enhances kidney stone prevention efforts.

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Magnesium Glycinate for Kidney Stone Prevention and Kidney Health

Magnesium glycinate is a highly absorbable form of magnesium that may support kidney health and reduce factors contributing to kidney stone formation. From reducing calcium oxalate crystallization to improving magnesium levels in the body, it plays a vital role in addressing the root causes of kidney stones.


Combined with a healthy diet, proper hydration, and lifestyle changes, magnesium glycinate may help reduce the risk of developing kidney stones when combined with proper hydration and dietary adjustments. Always consult a healthcare provider for personalized guidance on supplementation and kidney stone prevention.

Frequently Asked Questions

Can Magnesium Glycinate Dissolve Existing Kidney Stones?

Magnesium glycinate cannot dissolve existing kidney stones, but it can help prevent the formation of new stones by reducing oxalate absorption and calcium oxalate crystallization.

How Long Does It Take to See Benefits?

The preventive benefits of magnesium glycinate may become noticeable within a few weeks to months when taken consistently with proper hydration and dietary changes.

Are There Other Supplements That Help with Kidney Stones?

Potassium citrate and magnesium citrate are additional supplements that may help prevent kidney stones by increasing citrate excretion and reducing stone formation.

Is Magnesium Glycinate Safe for Everyone?

Magnesium glycinate is generally safe, but individuals with kidney disease or on certain medications should consult a doctor before use.

Can Magnesium Supplements Replace Dietary Magnesium?

Supplements like magnesium glycinate are beneficial but should complement a diet rich in magnesium-containing foods for optimal kidney health.


Medical Disclaimer:

The information provided in this article is for educational and informational purposes only and should not be considered a substitute for professional medical advice, diagnosis, or treatment. Please consult with your healthcare provider before starting any new dietary supplement, especially if you are pregnant, nursing, have a medical condition, or are taking other medications. Never disregard professional medical advice or delay in seeking it because of something you have read in this article.

References

  1. Grases, F., Costa-Bauza, A., & Prieto, R. M. (2006). Renal lithiasis and nutrition. Nutrition journal, 5, 23. https://doi.org/10.1186/1475-2891-5-23

  2. Jahnen-Dechent, W., & Ketteler, M. (2012). Magnesium basics. Clinical kidney journal, 5(Suppl 1), i3–i14. https://doi.org/10.1093/ndtplus/sfr163

  3. National Institutes of Health. (2022). Magnesium - Health Professional Fact Sheet. https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/

  4. Pak C. Y. (1994). Citrate and renal calculi: an update. Mineral and electrolyte metabolism, 20(6), 371–377. https://pubmed.ncbi.nlm.nih.gov/7783699/

  5. Schuette, S. A., Lashner, B. A., & Janghorbani, M. (1994). Bioavailability of magnesium diglycinate vs magnesium oxide in patients with ileal resection. JPEN. Journal of parenteral and enteral nutrition, 18(5), 430–435. https://doi.org/10.1177/0148607194018005430

  6. Taylor, E. N., & Curhan, G. C. (2013). Dietary calcium from dairy and nondairy sources, and risk of symptomatic kidney stones. The Journal of urology, 190(4), 1255–1259. https://doi.org/10.1016/j.juro.2013.03.074

  7. Workinger, J. L., Doyle, R. P., & Bortz, J. (2018). Challenges in the Diagnosis of Magnesium Status. Nutrients, 10(9), 1202. https://doi.org/10.3390/nu10091202 

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