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Test tube with blood representing uric acid blood test.

What Does Uric Acid Do to the Body? Understanding Its Effects

Uric acid is a natural waste product created when the body breaks down chemicals called purines, found in certain foods and cells. While most uric acid dissolves in the blood and is excreted through the kidneys, imbalances can lead to health problems like gout, kidney stones, and chronic kidney disease.


Understanding what uric acid does to the body and how high or low levels affect overall health is essential for disease prevention and maintaining a healthy balance.

Man with inflamed joints due to high uric acid.

What is Uric Acid?

Uric acid is a chemical produced when the body breaks down purines, natural substances found in certain foods and the body’s cells. It dissolves in the blood, travels to the kidneys, and is usually excreted through urine.


Normal uric acid levels generally range between 2.4 and 6.0 mg/dL for women and 3.4 and 7.0 mg/dL for men, though ranges may vary by laboratory or population. Maintaining a normal uric acid level within the healthy range is crucial to preventing health problems like gout and kidney problems.

Test tube with blood sample for uric acid testing.

How is Uric Acid Produced and Excreted?

Uric acid is produced during purine metabolism and excreted through the kidneys. Proper excretion ensures uric acid levels remain in a healthy range, preventing complications.

Purine Metabolism

Purines are essential compounds in the body. They are found in every cell and are involved in critical functions like DNA and RNA production. When the body breaks down purines, uric acid is produced as a natural byproduct. Normally, this uric acid dissolves in the blood and is eliminated through the kidneys. However, excessive purine breakdown can lead to an elevated uric acid level, increasing the risk of conditions like gout and kidney disease.


Dietary sources of purines include organ meats, red meat, seafood such as sardines and mackerel, and certain plant-based foods like dried beans and lentils. Foods and drinks high in fructose, such as sugary beverages and high fructose corn syrup, can also elevate uric acid production. Limiting these high-purine foods and sugar-sweetened beverages is essential for those at risk of developing gout or kidney problems.

Doctor showing kidney filtration and urine excretion.

Kidney Function

The kidneys play a vital role in maintaining healthy uric acid levels by filtering excess uric acid from the blood and excreting it through urine. This process ensures that uric acid stays within the normal range in the bloodstream. When the kidneys are functioning properly, they effectively prevent a buildup of crystals that can lead to health issues.


Compromised kidney function, often due to chronic kidney disease or other health conditions, can hinder the ability to excrete uric acid efficiently. As a result, too much uric acid may develop, increasing the likelihood of gout, kidney problems, and other health complications. Maintaining uric acid balance is crucial to supporting kidney health through proper hydration, a balanced diet, and regular checkups.

Effects of High Uric Acid Levels on the Body

Too much uric acid levels can have widespread effects, contributing to various health problems such as gout, kidney disease, and cardiovascular risks. Early detection and management are vital to avoid long-term damage to the joints, kidneys, and other organs.

Gout

Excess uric acid in the bloodstream can form sharp, needle-like crystals in joints, which can develop gout, a painful form of arthritis. These uric acid crystals trigger inflammation, leading to severe pain and swelling in affected joints.


Symptoms of gout include:


  • Intense, sudden joint pain, often in the big toe

  • Redness, warmth, and swelling in the affected area

  • Gout attacks that occur suddenly, often at night


Treatment options include:


Kidney Stones

When uric acid builds up in the urine, it can form solid crystals that develop into kidney stones. These stones can block the urinary tract, causing significant pain and complications.


Symptoms of kidney stones include:


  • Sharp pain in the back, side, or lower abdomen

  • Blood in the urine

  • Frequent or painful urination



Prevention strategies include:


  • Drinking adequate water supports kidney function, which may help in managing uric acid levels

  • Limiting high-purine foods and high fructose corn syrup

  • Monitoring uric acid levels through blood and urine tests

Joint Pain and Inflammation

High uric acid levels can lead to chronic inflammation in joints, resulting in joint pain and reduced mobility. Over time, untreated gout resulting from persistently high uric acid levels can lead to chronic joint damage or deformities.


Managing joint pain related to too much uric acid includes using anti-inflammatory medications, engaging in low-impact exercises to strengthen joints, and following a healthy diet to lower uric acid levels. Achieving and maintaining a healthy weight can also alleviate pressure on joints and reduce uric acid production.

Cardiovascular Health

Research has linked high uric acid levels to an increased risk of heart disease and other cardiovascular problems. Research suggests a possible association between elevated uric acid and an increased risk of high blood pressure, inflammation in blood vessels, and atherosclerosis (plaque buildup in arteries), though causation remains under investigation.


Maintaining levels within a healthy range is essential to reducing the cardiovascular risks associated with elevated uric acid. This can be achieved through a balanced diet low in high-purine foods, regular exercise, and managing related conditions such as hypertension and diabetes.

Kidney stones with measuring tape.

Symptoms of High Uric Acid Levels

Elevated uric acid levels can lead to several noticeable symptoms, ranging from mild to severe. Identifying these signs early can help prevent more serious complications.

Common Symptoms

Elevated uric acid levels often cause discomfort in joints and surrounding tissues due to the buildup of uric acid crystals. Symptoms may worsen during gout attacks.


Common symptoms include:


  • Pain in joints, particularly the big toe

  • Swelling and redness in the affected area

  • Joint stiffness and reduced mobility

Severe Symptoms

When high uric acid levels persist, they can cause more serious health issues that may affect multiple body systems. A healthcare provider should address these signs immediately.


Severe symptoms include:


  • Formation of kidney stones, leading to intense pain

  • Chronic joint damage or deformities

  • Increased risk of kidney disease or cardiovascular problems

Swelling ankle due to gout.

Diagnosis and Monitoring of Uric Acid Levels

Accurate diagnosis and ongoing monitoring are essential for managing uric acid levels and preventing complications.

Medical History and Physical Examination

During a doctor’s visit, the provider reviews your medical history and asks about symptoms such as joint pain or swelling. They may also perform a physical exam to check for signs of gout, joint inflammation, or other related conditions. Additional questions about your diet, lifestyle, and family history of gout or kidney problems help identify risk factors.

Blood Tests

Blood tests are a key tool for diagnosing elevated levels of uric acid. A uric acid test measures the amount of uric acid in your bloodstream, with results expressed in milligrams per deciliter (mg/dL). Healthy uric acid blood test levels are typically between 2.4 and 6.0 mg/dL for women and 3.4 and 7.0 mg/dL for men.


Understanding your urine test and uric acid test results is crucial. Uric acid blood levels above the normal range may indicate hyperuricemia, which increases the risk of gout, kidney problems, and other health problems. Your doctor may recommend further tests to confirm the diagnosis or identify underlying conditions.

Small test tube with blood sample.

Imaging Tests

In some cases, imaging tests are needed to assess damage caused by uric acid buildup or to detect conditions like gout or kidney problems. These tests provide a clearer picture of how uric acid affects your body.


Common imaging tests include:


  • X-rays to detect joint damage

  • Ultrasounds to locate uric acid crystals in joints

  • CT scans to identify kidney problems

Managing Uric Acid Levels

Managing uric acid levels is essential for preventing complications and maintaining overall health. Several strategies can help achieve this goal.

Dietary Changes

A healthy diet can significantly reduce uric acid levels. Avoiding high-purine foods and including beneficial options can make a big difference.


Dietary tips include:


  • Avoid organ meats, red meat, and high-fructose corn syrup

  • Limit alcohol and sugary beverages

  • Include more low-purine foods like fruits, vegetables, and whole grains

  • Opt for plant-based proteins like lentils and tofu

Hydration

Staying hydrated supports kidney function and may aid in the excretion of uric acid. Proper hydration reduces the risk of uric acid buildup and kidney stone formation.


Tips for staying hydrated include:


  • Drink at least 8–10 glasses of water daily

  • Include water-rich foods like cucumbers and watermelon

  • Avoid excessive caffeine or alcohol, which can dehydrate the body

Medication Management

Medications are often prescribed to help lower uric acid levels and manage related symptoms. Common medications include allopurinol, which reduces uric acid production, and colchicine, which helps relieve gout symptoms during an attack.


Discussing medication options with your doctor is important. Share any health conditions, allergies, or current medications to ensure the best treatment plan for your needs. Regular follow-ups help monitor progress and adjust dosages as necessary.

Lifestyle Modifications

Lifestyle changes are crucial for maintaining healthy uric acid levels and preventing complications. Achieving a healthy weight through a balanced diet and regular exercise reduces the risk of gout and other related health issues.


Effective strategies include:


  • Engaging in moderate exercise, like walking or swimming, to reduce inflammation

  • Avoiding crash diets, which can temporarily increase uric acid levels

  • Managing stress, as it can trigger gout flares and other symptoms

Preventing High Uric Acid Levels

Preventing elevated uric acid levels involves adopting healthy habits and monitoring your health regularly. Simple lifestyle changes and routine check-ups can help maintain a healthy balance.

Regular Check-Ups

Regular medical check-ups are essential for detecting elevated uric acid levels early and related health conditions. Your doctor may perform a uric acid test or urine test to measure levels and assess your risk of complications like gout or kidney disease. These tests are critical if you have risk factors such as a family history of gout or kidney disease.


Monitoring uric acid levels during routine visits helps track your progress and detect any changes early. Regular check-ups allow your healthcare provider to adjust treatments or recommend lifestyle changes to prevent long-term issues.

Preventive Measures

Daily habits like staying hydrated and eating a balanced diet can help keep uric acid levels within the normal range. Avoiding high-purine foods, sugary drinks, and excessive alcohol consumption reduces the risk of gout and other complications.


Long-term strategies for prevention include maintaining a healthy weight, exercising regularly, and avoiding stress. Consistency is key to preventing uric acid buildup and supporting overall health. Working with your doctor to create a personalized plan can ensure long-term success.

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Managing Uric Acid for Better Health

Uric acid plays a significant role in the body, but high levels can lead to serious health problems like gout, kidney stones, and joint damage. Managing uric acid levels through lifestyle changes, medical check-ups, and proper treatment may help lower the risk of complications. Consult your healthcare provider for personalized advice on managing uric acid levels and maintaining overall health.

Frequently Asked Questions

Can a high uric acid level be cured?

Elevated uric acid levels cannot be permanently cured, but they can be effectively managed through medication, lifestyle changes, and regular monitoring.

How quickly can uric acid levels be lowered?

The timeline for lowering uric acid levels depends on individual treatment plans, but significant improvements can often be seen within weeks to months.

What foods should I avoid to prevent high uric acid?

To reduce uric acid levels, avoid foods high in purines, such as red meat, organ meats, and shellfish, as well as sugary drinks and alcohol.

Are high uric acid levels always harmful?

Elevated uric acid levels are not always harmful but can lead to conditions like gout and kidney stones if untreated, so monitoring is important.

What are the common signs of high uric acid levels?

Common signs include joint pain, redness, swelling, and symptoms of gout or kidney stones, such as severe pain and blood in the urine.

Medical Disclaimer:

The information provided in this article is for educational and informational purposes only and should not be considered a substitute for professional medical advice, diagnosis, or treatment. Please consult with your healthcare provider before starting any new dietary supplement, especially if you are pregnant, nursing, have a medical condition, or are taking other medications. Never disregard professional medical advice or delay in seeking it because of something you have read in this article.

References

  1. Borghi, C., Agnoletti, D., Cicero, A. F. G., Lurbe, E., & Virdis, A. (2022). Uric Acid and Hypertension: a Review of Evidence and Future Perspectives for the Management of Cardiovascular Risk. Hypertension (Dallas, Tex. : 1979), 79(9), 1927–1936. https://doi.org/10.1161/HYPERTENSIONAHA.122.17956

  2. Choi, H. K., & Curhan, G. (2008). Soft drinks, fructose consumption, and the risk of gout in men: prospective cohort study. BMJ (Clinical research ed.), 336(7639), 309–312. https://doi.org/10.1136/bmj.39449.819271.BE

  3. Dalbeth, N., Merriman, T. R., & Stamp, L. K. (2016). Gout. Lancet (London, England), 388(10055), 2039–2052. https://doi.org/10.1016/S0140-6736(16)00346-9

  4. Johnson, R. J., Nakagawa, T., Jalal, D., Sánchez-Lozada, L. G., Kang, D. H., & Ritz, E. (2013). Uric acid and chronic kidney disease: which is chasing which?. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 28(9), 2221–2228. https://doi.org/10.1093/ndt/gft029

  5. Richette, P., & Bardin, T. (2010). Gout. The Lancet, 375(9711), 318–328. https://doi.org/10.1016/S0140-6736(09)60883-7

  6. Tausche, A. K., Jansen, T. L., Schröder, H. E., Bornstein, S. R., Aringer, M., & Müller-Ladner, U. (2009). Gout--current diagnosis and treatment. Deutsches Arzteblatt international, 106(34-35), 549–555. https://doi.org/10.3238/arztebl.2009.0549 

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